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Monday, August 24, 2015

Research that validates the health benefits of blackcurrant extract


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View the Evidence: Substances

A 12-week supplement of purified anthocyanin improved insulin resistance, indicators of liver injury, and clinical evolution in NAFLD patients.

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Medicine (Baltimore). 2015 May ;94(20):e758. PMID: 25997043
Article Published Date : Apr 30, 2015
Study Type : Human Study
Additional Links
Substances : Anthocyanins : CK(196) : AC(22), Bilberry : CK(43) : AC(12), Black Currant : CK(114) : AC(11)
Diseases : Nonalcoholic fatty liver disease (NAFLD) : CK(55) : AC(16)
Pharmacological Actions : Hepatoprotective : CK(632) : AC(282), Hypoglycemic Agents : CK(730) : AC(162)
Additional Keywords : Treatment Outcome

A blackcurrant product regulated the microbiota of volunteers and decreased the activity of βeta glucuronidase.

Pubmed Data : Phytother Res. 2014 Mar ;28(3):416-22. Epub 2013 May 15. PMID: 23674271
Article Published Date : Feb 28, 2014
Study Type : Human Study
Additional Links
Substances : Black Currant : CK(114) : AC(11), Lactoferrin : CK(117) : AC(30), Lutein : CK(124) : AC(22), Prebiotics : CK(114) : AC(15)
Diseases : Clostridium Infections : CK(171) : AC(30), Colon Cancer : CK(973) : AC(254), Colon Cancer: Prevention : CK(84) : AC(1)
Pharmacological Actions : Anticarcinogenic Agents : CK(756) : AC(282), Chemopreventive : CK(2013) : AC(530), Enzyme Inhibitors : CK(417) : AC(225)
Additional Keywords : Beta-glucuronidase, Plant Extracts : CK(5235) : AC(1645), Risk Reduction : CK(3534) : AC(355)

Black currant has immune-enhancing effect attributable to its ability to reduce prostaglandin E2.

Pubmed Data : Am J Clin Nutr. 1999 Oct;70(4):536-43. PMID: 10500023
Article Published Date : Oct 01, 1999
Study Type : Human Study
Additional Links
Substances : Black Currant : CK(114) : AC(11)
Diseases : Immune Disorders: Low Immune Function : CK(485) : AC(116)

Black currant anthocyanins caused a normalization of serum levels of ET-1 and may slow down glaucoma progression.

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Ocul Pharmacol Ther. 2013 Jun ;29(5):480-7. Epub 2012 Dec 21. PMID:23259919
Article Published Date : May 31, 2013
Study Type : Human Study
Additional Links
Substances : Anthocyanins : CK(196) : AC(22), Black Currant : CK(114) : AC(11)
Diseases : Glaucoma : CK(111) : AC(19), Optic Nerve Diseases : CK(5) : AC(3)
Pharmacological Actions : Antioxidants : CK(5120) : AC(1618), Endothelin-1 Inhibitor : CK(2) : AC(1)

Black currant polysaccharide assists in the treatment of Japanese cedar pollinosis.

Pubmed Data : Biosci Biotechnol Biochem. 2007 Dec;71(12):3019-25. Epub 2007 Dec 7 PMID:18071252
Article Published Date : Dec 01, 2007
Study Type : Human Study
Additional Links
Substances : Black Currant : CK(114) : AC(11)
Diseases : Allergic Rhinitis : CK(340) : AC(40), Pollinosis : CK(30) : AC(2)

Black currant seed oil supplementation of mothers enhances IFN-γ and suppresses IL-4 production in breast milk.

Pubmed Data : Pediatr Allergy Immunol. 2013 Sep ;24(6):562-6. PMID: 23980846
Article Published Date : Aug 31, 2013
Study Type : Human Study
Additional Links
Substances : Black Currant : CK(114) : AC(11)
Diseases : Atopic Dermatitis : CK(719) : AC(84), Prenatal Nutrition: Health of the Offspring : CK(236) : AC(34), Prenatal Nutrition: Prevention of Problems : CK(357) : AC(41)
Therapeutic Actions : Breastfeeding : CK(739) : AC(77)
Pharmacological Actions : Interferon-gamma (IFN-gamma) inducer : CK(12) : AC(6),Interleukin-4 downregulation : CK(71) : AC(12)

Blackcurrant juice could support the metaphylaxis and treatment of uric acid urolithiasis because of its alkalizing effect.

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Eur J Clin Nutr. 2002 Oct ;56(10):1020-3. PMID: 12373623
Article Published Date : Sep 30, 2002
Study Type : Human Study
Additional Links
Substances : Black Currant : CK(114) : AC(11), Cranberry : CK(226) : AC(42)
Diseases : Kidney Stones : CK(159) : AC(29), Urolithiasis : CK(8) : AC(5)
Additional Keywords : Alkalizing effect, Juice, Risk Reduction : CK(3534) : AC(355)

Blackcurrant seed oil is a potentially effective treatment for active rheumatoid arthritis.

Pubmed Data : Br J Rheumatol. 1994 Sep;33(9):847-52. PMID: 8081671
Article Published Date : Sep 01, 1994
Study Type : Human Study
Additional Links
Substances : Black Currant : CK(114) : AC(11)
Diseases : Arthritis: Rheumatoid : CK(295) : AC(53)

Blackcurrant seed oil is well tolerated and transiently reduces the prevalence of atopic dermatitis in newborns.

Pubmed Data : Clin Exp Allergy. 2010 Aug;40(8):1247-55. Epub 2010 Jun 9. PMID: 20545710
Article Published Date : Aug 01, 2010
Study Type : Human Study
Additional Links
Substances : Black Currant : CK(114) : AC(11)
Diseases : Atopic Dermatitis : CK(719) : AC(84), Atopic Dermatitis: Infant & Childhood : CK(170) : AC(14)

Postmeal fluctuations in blood glucose and insulin induced by sucrose are alleviated when sucrose is consumed with blackcurrants or lingonberries.

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Clin Nutr. 2012 Sep ;96(3):527-33. Epub 2012 Aug 1. PMID: 22854401
Article Published Date : Aug 31, 2012
Study Type : Human Study
Additional Links
Substances : Black Currant : CK(114) : AC(11), Lingonberry : CK(1) : AC(1)
Diseases : Hyperinsulinism : CK(1451) : AC(51)
Pharmacological Actions : Glucose Uptake Optimization : CK(16) : AC(1)
Additional Keywords : Metabolic regulation
Problem Substances : Insulin : CK(137) : AC(19), Sucrose : CK(34) : AC(9)

Supplementation with orange and blackcurrant juice improves inflammatory markers in patients with peripheral arterial disease.

Pubmed Data : Br J Nutr. 2009 Jan;101(2):263-9. Epub 2008 May 28. PMID: 18507878
Article Published Date : Jan 01, 2009
Study Type : Human Study
Additional Links
Substances : Black Currant : CK(114) : AC(11), Orange : CK(126) : AC(28), Sweet Orange : CK(12) : AC(2)
Diseases : Elevated CRP : CK(82) : AC(8), Fibrinogen: Elevated : CK(114) : AC(13),Inflammation : CK(1482) : AC(377), Peripheral Arterial Disease : CK(260) : AC(26)
Pharmacological Actions : Anti-Inflammatory Agents : CK(2167) : AC(682)
Additional Keywords : Oranges are Anti-inflammatory : CK(10) : AC(1)

The present work emphasizes the potential of berries in chemoprevention, especially CRC chemoprevention.

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2015;2015:154164. Epub 2015 Jun 9. PMID: 26180579
Article Published Date : Dec 31, 2014
Study Type : Human In Vitro
Additional Links
Substances : Black Currant : CK(114) : AC(11), Blackberry : CK(17) : AC(13), Blueberry : CK(159) : AC(47), Cranberry : CK(226) : AC(42), Indian Gooseberry : CK(1) : AC(1),Lingonberry : CK(1) : AC(1), Raspberry : CK(21) : AC(11)
Diseases : Colon Cancer : CK(973) : AC(254), Colon Cancer: Prevention : CK(84) : AC(1)
Pharmacological Actions : Apoptotic : CK(2058) : AC(1476), Caspase-8 activation : CK(22) : AC(6), Chemopreventive : CK(2013) : AC(530)
Additional Keywords : Dietary concentrations, Growing Your Own Food, Procyanidins

Anthocyanin rich bilberry and blackcurrant diets favorably modulate altered amyloid precursor protein processing and alleviate behavioral abnormalities in a mouse model of AD.

Pubmed Data : J Nutr Biochem. 2013 Jan ;24(1):360-70. Epub 2012 Sep 17. PMID: 22995388
Article Published Date : Dec 31, 2012
Study Type : Transgenic Animal Study
Additional Links
Substances : Anthocyanins : CK(196) : AC(22), Bilberry : CK(43) : AC(12), Black Currant : CK(114) : AC(11), Flavonoids : CK(1072) : AC(301), Quercetin : CK(412) : AC(143)
Pharmacological Actions : Neuroprotective Agents : CK(1347) : AC(665)
Additional Keywords : Plant Extracts : CK(5235) : AC(1645)

Anthocyanin-rich black currant extract affords chemoprevention against chemically-induced liver cancer in rats.

Pubmed Data : J Nutr Biochem. 2011 Jan 7. Epub 2011 Jan 7. PMID: 21216582
Article Published Date : Jan 07, 2011
Study Type : Animal Study
Additional Links
Substances : Anthocyanins : CK(196) : AC(22), Black Currant : CK(114) : AC(11)
Diseases : Chemically-Induced Liver Damage : CK(500) : AC(187), Liver Cancer : CK(829) : AC(287)
Pharmacological Actions : Bax/Bcl2 ratio: Increase : CK(7) : AC(6), Chemopreventive : CK(2013) : AC(530)

Black currant extract prevents negative lens-induced myopia in an animal model.

Pubmed Data : Ophthalmic Res. 2010 ;44(4):242-50. Epub 2010 Aug 10. PMID: 20699628
Article Published Date : Jan 01, 2010
Study Type : Animal Study
Additional Links
Substances : Black Currant : CK(114) : AC(11)
Diseases : Myopia : CK(15) : AC(3)
Additional Keywords : Plant Extracts : CK(5235) : AC(1645)

Black currant seed oil suppresses urate crystal-induced inflammation.

Pubmed Data : Pharmacol Res. 2005 Sep;52(3):216-22. PMID: 7741038
Article Published Date : Sep 01, 2005
Study Type : Animal Study
Additional Links
Substances : Black Currant : CK(114) : AC(11)
Diseases : Hyperuricemia : CK(169) : AC(40)

Blackcurrant pomace selectively modulated the enzymatic activity of the colon microflora, reducing the activity of enzymes with potentially harmful properties in high fructose diets.

Pubmed Data : J Anim Physiol Anim Nutr (Berl). 2015 May 3. Epub 2015 May 3. PMID:25939288
Article Published Date : May 02, 2015
Study Type : Animal Study
Additional Links
Substances : Black Currant : CK(114) : AC(11)
Diseases : Fructose-Induced Toxicity : CK(140) : AC(52), Liver Stress: Fructose-Induced : CK(19) : AC(10)
Pharmacological Actions : Anticholesteremic Agents : CK(791) : AC(140)

Blackcurrant powdered extract for 8 weeks reduced body weight gain and improved glucose metabolism only in mice with the intact gut microbiomes.

Pubmed Data : J Agric Food Chem. 2015 Jun 12. Epub 2015 Jun 12. PMID: 26066489
Article Published Date : Jun 11, 2015
Study Type : Animal Study
Additional Links
Substances : Anthocyanins : CK(196) : AC(22), Black Currant : CK(114) : AC(11)
Diseases : Dysbiosis : CK(236) : AC(38), Insulin Resistance : CK(1237) : AC(235), Obesity : CK(2013) : AC(288)
Additional Keywords : Anti-Obesity Agents : CK(106) : AC(27), Microbiota

Supplementation with a polyphenol rich blackcurrant extract decreased plasma total cholesterol, glucose, and inhibited liver steatosis in mice.

Pubmed Data : Br J Nutr. 2015 Apr 22:1-7. Epub 2015 Apr 22. PMID: 25899149
Article Published Date : Apr 21, 2015
Study Type : Animal Study
Additional Links
Substances : Black Currant : CK(114) : AC(11), Polyphenols : CK(664) : AC(182)
Diseases : Fatty Liver : CK(540) : AC(127), High Cholesterol : CK(1974) : AC(199), Metabolic Diseases : CK(31) : AC(3)
Pharmacological Actions : Hypolipidemic : CK(515) : AC(104)

Black currant extract suppresses the growth of human liver cancer cells.

Pubmed Data : Nat Prod Commun. 2010 Oct ;5(10):1613-8. PMID: 21121259
Article Published Date : Oct 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Anthocyanins : CK(196) : AC(22), Black Currant : CK(114) : AC(11)
Diseases : Liver Cancer : CK(829) : AC(287)
Pharmacological Actions : Antioxidants : CK(5120) : AC(1618), Antiproliferative : CK(1657) : AC(1133)
Additional Keywords : Plant Extracts : CK(5235) : AC(1645)

Black currant polysaccharides inhibit the adhesion of Helicobacter pylori to human gastric mucosa.

Pubmed Data : Arch Ophthalmol. 2009 May;127(5):674-80. PMID: 15254855
Article Published Date : May 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Black Currant : CK(114) : AC(11)
Diseases : Helicobacter Pylori Infection : CK(354) : AC(68)

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